Fatty Liver- No Longer Benign !

Abstract

NAFLD (Nonalcoholic Fatty Liver Disease) :
• NAFLD is the most common cause of chronic liver
disease in Western nations
th th
• 4 – 6 decades of life
• Men > Women
• Hepatic manifestation of metabolic syndrome
• Evidence of excessive fat accumulation in the form
of triglycerides (steatosis) in the liver by histology
(> 5% of hepatocytes) or imaging (> 33% of
hepatocytes)
• There should be no causes for secondary hepatic
fat accumulation
• >80% of NAFLD pts have an increased BMI
• 30-40% are obese
• ~50% show signs of insulin resistance
• 20-30% have type 2 diabetes
• 80% show hyperlipidemia
• Most common cause of death in patients with
NAFLD is cardiova