Clinicohematological profile of Splenic Marginal Zone Lymphomas- Case report series

Clinicohematological profile of Splenic Marginal Zone Lymphomas

Abstract

Background: Marginal zone lymphoma (MZL), an indolent B-cell lymphoproliferative disease, includes 3 entities: Mucosa-associated lymphatic tissue (MALT) lymphoma, splenic MZL (SMZL) and nodal MZL. Of these, the SMZL represents 20% of MZL, accounting for -less than 2% of all non-Hodgkin lymphomas. The median age of occurrence for SMZL is 65 years and it affects both genders equally.
Materials & Methods: We have retrospectively reviewed the clinical data of six patients diagnosed with SMZL at our institute in time duration of two years. The patients were diagnosed based on clinical history, marrow morphology along with cytochemistry and immunophenotyping (IPT).
Results: All six patients were found to have splenomegaly. All of them were positive for CD 20 and sIgM and negative for CD 5 and CD 103 while displayed variable expression for CD 11c, CD 23 and CD 25. Two of the cases were splenectomised, three of them received chemotherapy and one patient was lost to follow up. In one of the splenectomised case, normalisation of blood counts was noticed while the other four cases did not show any significant improvement in their disease manifestations..