Congenital Insensitivity to Pain and Anhidrosis: A Series of Three cases from Eastern India

Congenital Insensitivity to Pain and Anhidrosis: a series of three cases from Eastern India

Authors

  • Gautam Guha MS MCh
  • Debarati Chattopadhyay MS MCh
  • Suparna Guha MD
  • Gautam Guha MD DM
  • Subhadeep Das MD

Keywords:

Congenital insensitivity to pain, genetic disorder, self mutilation

Abstract

Congenital insensitivity to pain and anhidrosis (CIPA) is a very rare genetic disorder caused by mutations in the neurotrophic tyrosine receptor kinase 1 (NTRK1) gene in chromosome 1. The affected children present with congenital lack of pain sensation, inability to sweat, episodes of recurrent hyperpyrexia, mental retardation, and self-mutilating behavior. Here we describe three cases of CIPA from a teaching institute in eastern India.

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Published

2015-02-28

Issue

Section

Case Report