Nevirapine Induced Stevens-Johnson Syndrome (S-J Syndrome) with Ocular Complication in a HIV Positive Patient

Nevirapine Induced Stevens- Johnson Syndrome with Ocular Complication in a HIV Positive Patient

Abstract

Stevens - Johnson syndrome has been reported in 0.3% of patients taking Nevirapine as non nucleoside reverse transcriptase inhibitor in the Highly Active Anti- Retroviral Therapy within first four to six weeks of treatment. We report one such uncommon case in a young adolescent HIV infected male who developed generalized skin eruptions with mucous membrane involvement of genitalia, oral cavity and conjunctiva of Eye after one week of escalating dose of Nevirapine (200mg twice daily) following lead- in period of 14 days (200mg once daily) . There was improvement and healing of skin, mucous membrane and ocular lesions with aggressive management but developed chronic ocular complication in the form of symblepharon of both eyes on six month follow up. This case is reported to create awareness towards Nevirapine induced adverse drug reaction and recommend to withdraw Nevirapine if any cutaneous eruption occurs during first month of treatment as the mortality in moderate to severe cases of Stevens- Johnson Syndrome is around 30%.