Study of possible Analgesic activity of Buspirone.
Study of possible Analgesic activity of Buspirone.
DOI:
https://doi.org/10.70284/njirm.v6i2.879Keywords:
Buspirone ,analgesic, neuropathic , psychiatric, painAbstract
Background: Pain results from complex interactions in peripheral and central synapses.1The majority of current approaches to treating pain are based on the idea that increasing the level of inhibitory drive or tone at key central nervous system (CNS) regions in the pain pathway can alter pain perception2,3,4,5 Lot of neurotransmitters are implicated in it including 5-HT. Thus we were interested If buspirone is having analgesic effect.Our aim was to assess if buspiron has analgesic effect. And if comparative efficacy to drugs used today. Methodology: After appropriate IAEC clearance ,Hotplate , tail flick analgesiometer methods and acetic acid writhing test were employed. Comparative drugs used were amitriptyline and ibuprofen . Buspirone was used in doses of 2,4 ,mg/kg. Results: Our study showed a comparable efficacy of buspirone to ibuprofen in hot plate test while superior efficacy as an analgesic against amitriptyline at dose of 4mg/kg. Conclusion: 5-HT is considered pronociceptive but has shown differential activity in CNS and at peripheral tissues. Buspirone is a partial 5-HT 1A agonist and antianxiety drug. Due to the complex interactions at centers in CNS it was proposed to have analgesic action.Our study evaluated this theory with three analgesic models. Our results show that at doses 2 & 4mg/kg it has comparable effect to ibuprofen 20 mg/kg dose. At the same dose it shows superiority to amitriptyline 40mg/kg. Thus it shows promise in treatment of pain associated with anxiety induced depression or other psychiatric problems.[Limaye R NJIRM 2015; 6(2):44-49]
References
2. Millan MJ. Descending control of pain. Prog Neurobiol. 2002; 66(6):355-474.
3. Gebhart GF. Descending modulation of pain. Neurosci Biobehav Rev.2004; 27(8):729-737.
4. Woolf CJ, Salter MW. Neuronal plasticity: Increasing the gain in pain. Science 2000; 288(5472):1765-1769.
5. Sivilotti L, Woolf CJ. The contribution of GABA and glycine receptors to central sensitization: Disinhibition and touch-evoked allodynia in the spinal cord. J Neurophysiol. 1994; 72(1):169-179.
6. Blier P, Ward NM. Is there a role for 5-HT1A agonists in the treatment of depression?. Biol Psychiatry 2003; 53:193-203.
7. Fulton B, Brogden RN. Buspirone: an updated review of its clinical pharmacology and therapeutic applications. CNS Drugs 1997; 7: 68-88.
8. Barnes NM, Sharp T. A review of central 5-HT receptors and their function.Neuropharmacology 1999; 38: 1083-1152.
9. Bianchi M, Sacerdote P, Panerai AE. Chlomipramine differently affects inflammatory edema and pain in the rat. Pharmacol Biochem Behav 1994; 48: 1037-1040.
10. Abdel-Salam OME, Baiuomy AR, Arbid MS. Studies on the anti-inflammatory effect of fluoxetine in the rat. Pharmacological Research 2004; 49: 119-131.
11. Shaw S, Nihal M, Ahmed N. Dose translation from animal to human studies revisited. The FASEB Journal 2007;22:659-661.
12. Le Bars D, Gozariu M & Cadden SW . Animal models of nociception: Pharmacological Reviews. 2001; 53: 597-652.
13. Ghosh M.N. Fundamentals of Experimental Pharmacology. 3rd ed. Kolkata:Hilton and Co; 2005.
14. Medhi B, Prakash A. Practical Manual of Experimental and Clinical Pharmacology.1st ed.
15. Abdel-Salam OME, Baiuomy AR. Effect Of Buspirone On Inflammation, Pain And Gastric Injury In Mice. The Internet Journal of Pharmacology. 2008; 6(1).
16. Paudel KR, Das BP, Rauniar GP, Deo S & Bhattacharya SK. Antinociceptive effect of Amitriptyline in mice of acute pain model. Indian Journal of Experimental Biology. 2007 June; 45; 529-531.
17. Meena MK, Jain AK, Gaur K. Screening of Anti-inflammatory and analgesic acivity of Cassia grandis linn. Academic journal of plant Sciences 2009; 2(1): 51-55.
18. Howard B Gutstein and Huda Akil.Opioid analgesics. Goodman and Gilman’s The pharmacological basis of Therapeutics, 11th ed McGraw Hill; 547-590.
19. McQuay HJ and Moore RA. Antidepressants and chronic pain.Br Med J. 1997;314:763-764.
20. Watson CP, Evans RJ, Reed K, et al. Amitriptyline versus placebo in postherpetic neuralgia. Neurology 1982; 32:671-673.
21. Galeotti N, Ghelardini C, Bartolini A. 5-HT1A agonists induce central cholinergic antinociception. Pharmacology, biochemistry, and behaviour.1997; 57(4):835-841.
22. Robles LI, Barrios M, Del Pozo E, Dordal A, Baeyens JM. Effects of K+ channel blockers and openers on antinociception induced by agonists of 5-HT1A receptors. Eur J Pharmacol. 1996; 295: 181-188.
23. Kiss I, Degryse AD, Bardin L, Gomez de Segura IA, Colpaert FC. The novel analgesic, F 13640, produces intra- and postoperative analgesia in a rat model of surgical pain. Eur J Pharmacol. 2005; 523(1–3):29-39.
24. Millan MJ, Colpaert FC. Attenuation of opioid induced antinociception by 5-HT1A partial agonists in the rat. Neuropharmacology. 1990; 29(3):315-318.
25. Sivarao DV, Newberry K, Lodge NJ. Effect of the 5HT1A receptor partial agonist buspirone oncolorectal distension-induced pseudoaffective and behavioral responses in the female Wistar rat. Eur J Pharmacol. 2004; 494: 23-29.
26. Giordano J, Rogers L. Putative mechanisms of buspirone-induced antinociception in the rat. Pain. 1992; 50: 365-72.
27. Liang JH ,Wang XH ,Liu RK,Sun HL,Ye XF, Zheng JW. Buspirone-induced antinociception is mediated by L-type calcium channels and calcium/caffeine-sensitive pools in mice. Psychopharmacology (Berl) 2003;166:276-83.
28. Millan N.J. Serotonin and pain: evidence that activation of 5-HT1A receptors does not elicit antinociception against noxious thermal, mechanical and chemical stimuli in mice.Pain. 1994; 58(1):45.
29. CaoB.J., LiW.P. Antagonism of clonidine antinociception by buspirone and 1-(2-pyrimidinyl)-piperazine. Eur.J.Pharmacol. 1994; 259(1): 75.
30. Liu ZY, Zhuang DB, Lunderberg T, Yu LC. Involvement of 5- hydroxytryptamine(1A) receptors in the descending anti-nociceptive pathway from periaqueductal gray to the spinal dorsal horn in intact rats, rats with nerve injury and rats with inflammation. Neuroscience. 2002; 112(2):399-407.
31. Magni G. On the relationship between chronic pain and depression when there is no organic lesion, Pain 1987; 31:1-21.
32. Kedare R, Ghongane BB. Evaluation of activity of buspirone against pain in animal models. International Journal of Pharma and Bio Sciences, Jan-March 2012; 3(1).
