Chronic Smoking, a Cause for Development of Peripheral Neuropathy in Chronic Obstructive Pulmonary Disease
Chronic Smoking, a Cause for Development
Keywords:
chronic obstructive pulmonary disease, cigarette smoking, duration of smoking history, peripheral neuropathyAbstract
Background: Cigarette smoking is the most commonly encountered risk factor for COPD, and causes COPD by its noxious particles and or gases. Cigarette smoke contains some neurotoxin substances that might be important in the pathogenesis of peripheral neuropathy. Objective: To determine whether the effect of the duration of smoking leads to development of peripheral neuropathy in different groups of the COPD patients as measured by nerve conduction studies of upper extremities Material and Methods: The nerve conduction test, of the median and ulnar nerves of the upper extremities, was performed on the subjects (study and control group), who were assessed for their anthropometric measurements, history regarding pack years, the pulmonary function tests, SpO2 levels. Results: Significant difference was found between smoking history in pack years and in the values of Nerve Conduction Velocity of the nerves of upper extremities in different groups of COPD patients, which was found to be statistically significant at p<0.001. Conclusion: A decrease in nerve conduction velocity was observed in the nerves of upper extremities as duration of smoking in pack years increased in the different groups of COPD patients. [Garg A NJIRM 2014; 5(6):1-6]
References
2. Pauwels RA, Buist AS, Calverley PM, Jenkins CR. Hurd SS. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J RespirCrit Care Med. 2001; 163: 1256-1276. Available at internet address www.atsjournals.org
3. Agust´A G. N. Systemic Effects of Chronic Obstructive Pulmonary Disease. Proc Am Thorac Soc. 2005; 2:367–370. Available at internet address www.atsjournals.org
4. Ozge A, Atis S, Sevim S. Subclinical peripheral neuropathy with chronic obstructive pulmonary disease. Electro myogr Clin Neurophysiol. 2001; 41:185- 191.
5. Stratelis G, Jakobsson P, Molstad S and Zetterstrom O. Early detection of COPD in
primary care: screening by invitation of smokers aged 40 to 55 years. British Journal of General Practice.2004; 54: 201-206.
6. Mishra UK, Kalita J. Clinical Neurophysiology, 2ndedn. New Delhi Elsevier, Reed Elsevier India Private Limited. 2004:12-218.
7. ManninoD M, Gagnon RC, Petty T L, Lydick E. Obstructive Lung Disease and Low Lung Function in Adults in the United States Data From the National Health and Nutrition Examination Survey 1988-1994. Arch Intern Med. 2000; 160(11) : 1683-1689.
8. Agrawal D, Vohra R, Gupta PP, Sood S. Subclinical peripheral neuropathy in stable middle-aged patients with chronic obstructive pulmonary disease.Singapore Med J. Oct 2007; 48(10):887-94.
9. Padmavathy KM: Comparative Study of Pulmonary Function Variables in Relation to Type of Smoking. Indian J Physiol Pharmacol.2008;52(2):193-196.
10. Stav D and Raz M. Prevalence of Chronic Obstructive Pulmonary Disease among Smokers Aged 45 and Up in Israel. IMAJ. 2007; 9:800–802.
11. Faden A, Mendoza E, Flynn F. Subclinical neuropathy associated with chronic obstructive pulmonary disease possible pathophysiologic role of smoking.Arch Neurol. 1981 Oct; 38(10):639-42.
12. Gokhan A, Cakan A, Erbaycu A E, DereliS, Özsöz A, Edipoğlu H. Electromyographic Evaluation Of Peripheral Nerves In Chronic Obstructive Pulmonary Disease. Turkish Respiratory Journal. Aug 2003; 4(2):51-56
13. MayerP, Dematteis M, PépinJL, WuyamB, VealeD, VilaA, etal.Peripheral Neuropathy In Sleep Apnea A Tissue Marker Of The Severity Of Nocturnal Desaturation. Am J RespirCrit Care Med. Jan 1999; 159(1): 213-219.
14. Narayan M, Ferranti R. Nerve Conduction Impairment in Patients with Respiratory Insufficiency and Severe Chronic Hypoxemia. Arch Phys Med Rehabil.1978; 59: 188-92.
15. Nowak D, Brúch M, Arnaud F, Fabel H,Kiessling D, Nolte D et al. Peripheral neuropathies in patients with chronic obstructive pulmonary disease: A multicenter prevalence study. Lung.1990; 168:43-51.
