Heparin Resistance in a COVID-19 patient: A Rare Occurrence

  • Dr. Khushali Parikh NHL Municipal Medical College, Ahmedabad
  • Dr. Sapna Gupta Assistant Professor, Department of Emergency Medicine, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India-380006
  • Dr. Supriya Malhotra Professor and Head, Department of Pharmacology, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India-380006
  • Dr. Pratik Patel Dean, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India-380006
Keywords: Heparin Resistance (HR), COVID-19, Coagulopathy, Heparin, Low Molecular Weight Heparin (LMWH), Dalteparin

Abstract

Coronavirus disease-2019 (COVID-19) in severe cases is associated with marked inflammation in mainly the lungs. Reports suggest a beneficial role of heparin/low molecular weight heparin (LMWH) in reducing mortality and morbidity in such patients. We have summarized potential beneficial, anti-inflammatory mechanisms underlying treatment of COVID-19 patients with heparin/LMWH. Herein, we present a rare case of severe COVID-19 showing Heparin Resistance (HR), which was primarily suspected due to constantly elevated inflammatory markers like CRP, D-dimer, IL-6 and subtherapeutic levels of aPTT when the patient was on Heparin. These parameters showed remarkable changes when Heparin was replaced by LMWH, Dalteparin and eventually the condition of patient ameliorated.

References

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Published
2021-01-15
How to Cite
Parikh, D. K., Gupta, D. S., Malhotra, D. S., & Patel, D. P. (2021). Heparin Resistance in a COVID-19 patient: A Rare Occurrence. National Journal of Integrated Research in Medicine, 11(6), 66-68. Retrieved from http://nicpd.ac.in/ojs-/index.php/njirm/article/view/2897
Section
Case Report