Heparin Resistance in a COVID-19 patient: A Rare Occurrence

  • Dr. Khushali Parikh NHL Municipal Medical College, Ahmedabad
  • Dr. Sapna Gupta Assistant Professor, Department of Emergency Medicine, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India-380006
  • Dr. Supriya Malhotra Professor and Head, Department of Pharmacology, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India-380006
  • Dr. Pratik Patel Dean, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India-380006
Keywords: Heparin Resistance (HR), COVID-19, Coagulopathy, Heparin, Low Molecular Weight Heparin (LMWH), Dalteparin


Coronavirus disease-2019 (COVID-19) in severe cases is associated with marked inflammation in mainly the lungs. Reports suggest a beneficial role of heparin/low molecular weight heparin (LMWH) in reducing mortality and morbidity in such patients. We have summarized potential beneficial, anti-inflammatory mechanisms underlying treatment of COVID-19 patients with heparin/LMWH. Herein, we present a rare case of severe COVID-19 showing Heparin Resistance (HR), which was primarily suspected due to constantly elevated inflammatory markers like CRP, D-dimer, IL-6 and subtherapeutic levels of aPTT when the patient was on Heparin. These parameters showed remarkable changes when Heparin was replaced by LMWH, Dalteparin and eventually the condition of patient ameliorated.


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How to Cite
Parikh, D. K., Gupta, D. S., Malhotra, D. S., & Patel, D. P. (2021). Heparin Resistance in a COVID-19 patient: A Rare Occurrence. National Journal of Integrated Research in Medicine, 11(6), 66-68. Retrieved from http://nicpd.ac.in/ojs-/index.php/njirm/article/view/2897
Case Report