A Study Of Relation Of C- Reactive Protein With Hemoglobin, Platelet Count, Creatinine And Bilirubin Levels In Patients Of Malaria

Relation Of CRP With Severity Of Malaria

Abstract

Background: The burden of malaria warrants need of predicting severity of malaria early. CRP is a known acute phase reactant. Objectives: To find out if there is any correlation between CRP at the time of presentation with later complications in malaria. Material And Methods: This was an observational study. All patients ≥ 18 years with confirmed diagnosis of malaria were included. The data was analysed correlation of CRP at presentation with hemoglobin, platelet count, liver enzymes or creatinine levels. Result: Total 80 patients were included. There was positive correlation of CRP with T. bilirubin, SGPT, s.creatinine and blood urea (r = 0.21, 0.26, 0.51 and 0.44 respectively) while there was negative correlation of CRP with Hb and platelet count (r = -0.26, -0.56). A statistically significant difference was observed in values of haemoglobin, platelet count and serum creatinine between the two groups with CRP > 6 mg/l and CRP < 6mg/l. Conclusion: CRP at presentation in cases of malaria is positively correlated with s. bilirubin, liver enzymes and s creatinine and negatively correlated with hemoglobin and platelet counts. CRP should be tested in all malaria patients to identify patients requiring aggressive treatment to prevent serious complications of malaria and improve prognosis. [Kanojiya S Natl J Integr Res Med, 2020; 11(4):42-46]