Evaluation Of Impact Of Cigarette Smoking On Platelet Parameters And Coagulation Profile In Young Healthy Male Subjects

Evaluation Of Impact Of Cigarette Smoking On Platelet Parameters and Coagulation profile

Abstract

Aim: This study aims to assess the impact of smoking on platelet parameters and coagulation profile in young healthy smokers. Material And Methods: A total of 100 apparently healthy males, aged between 20–50 years were taken. 60 smokers who have smoked regularly for a minimum of 1year and 40 age and sex matched non-smokers/controls were included in the study. The smokers were further classified into light and heavy smokers according to ‘Pack Years’. 2ml EDTA and 2ml citrated blood samples were withdrawn to perform CBC and coagulation profile respectively. The levels of these parameters were recorded and statistically analysed. Result: The study shows that frequency and duration of smoking is directly proportional to the adverse effects on the body. We found that there was significant increase in WBC count in chronic smokers (>8000 106/L) consistent with other published reports. There was significant reduction in platelet count found in chronic smokers more than light smokers. We also observed that increased duration and frequency of cigarette smoking was associated with significant shorter PT (10.94 s) and APTT (27.29 s) in heavy smokers. Conclusion: Hence we conclude that cigarette smoking should be strictly discouraged. Awareness about deleterious effects produced by smoking should be done as harmful effects of smoking are reversible if stopped at an early phase. [Jain A Natl J Integr Res Med, 2019; 10(5):53-57]