Efficacy Of Oral Brush Cytology In The Detection Of Oral Malignant And Premalignant Lesions
Efficacy Of Oral Brush Cytology In The Detection Of Oral Malignant And Premalignant Lesions
Keywords:
Brush cytology , Exfoliative cytology , Haematoxylin and Eosin , May Grunwald GiemsaAbstract
Introduction : Oral cancers account for approximately 3% of all malignancies and is a significant worldwide health problem. Globally, oral cancers are one of the 10 most common cancers and accounts for almost 40% of all cancers in Indian subcontinent.. A key factor in the lack of improvement in prognosis is the fact that a significant proportion of oral squamous cell carcinomas are not diagnosed and treated until they reach an advanced stage. Material and Method: The present study has been carried out on 50 patients suffering from oral cavity lesion. In all patients oral brush cytology using a toothbrush was done prior to a planned surgical biopsy. The study was done to assess the efficacy of oral brush cytology in detecting the premalignant and malignant lesions and its use as an early diagnostic aid. Result: 25 Cases were true positive on both histopathology and oral brush cytology. 20 Cases were true negative and 5 Cases were suspicious for malignancy on brush cytology, they were diagnosed as malignant on further histopathological examination. A sensitivity of 80% , specificity of 100% , negative predictive value was 83.3% , positive predictive value was 100% and accuracy was 90%. Conclusion: Oral brush cytology is an accurate diagnostic tool that plays a significant role in early cancer detection. It is also useful as a screening procedure for a high risk population or also for the clinical follow up. [Sharma S Natl J Integr Res Med, 2018; 9(6):13-17]
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