Immunomodulatory activity of Guduchi Ghana (Aqueous Extract of Tinospora Cordifolia Miers)
Immunomodulatory activity of Guduchi Ghana
Keywords:
Guduchi (Tinospora Cordifolia); Ghana Kalpana (aqueous extract); Immunomodulatory activity; Cellular mediated immunity; % Haemagglutination antibody titreAbstract
In the present work, Guduchi Ghana (concentrated form of aqueous extract of Guduchi) was prepared according to the method described in classical text – Sidhdha Yoga Samgraha and the other sample of aqueous extract was purchased from the market for the assessment of the immunomodulatory activity. It was done by haemagglutination antibody titre method for humoral immunity and footpad swelling method for cell mediated immunity on wistar albino rats. Results of present studies suggest that Guduchi Ghana prepared by classically was found to possess significant immunostimulatory action on immune system but market sample of it exhibited significant immunosuppression effect in dose dependent manner when compare with control group at a dose of 50 mg/kg orally
References
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2. Bhava Mishra, Bhava Prakasha Nighantu, Commentry by K.C. Chunekar, 2010, Chaukhambha Bharti Academy, Varanasi, 3:257.
3. Anonymous. Wealth of India: Raw materials, Vol X. New Delhi: CSIR; 1976, 251.
4. Nagarkatti DS, Rege NN, Desai NK, Dahanukar SA. Modulation of Kupffer cell activity by Tinospora cordifolia in liver damage. J Postgrad Med. 1994; 40:65–7.
5. Rege N, Bapat RD, Koti R, Desai NK, Dahanukar S. Immunotherapy with Tinospora cordifolia: A new lead in the management of obstructive jaundice. Indian J Gastroenterol. 1993; 12:5
6. Rege NN, Nazareth HM, Bapat RD, Dahanukar SA. Modulation of immunosuppression in obstructive jaundice by Tinospora cordifolia. Indian J Med Res. 1989; 90:478–83.
7. Manjrekar PN, Jolly CI, Narayanan S. Comparative studies of the immunomodulatory activity ofTinospora cordifolia and Tinospora sinensis. Fitoterapia. 2000;71:254–7.
8. Dikshit V, Damre AS, Kulkarni KR, Gokhale A, Saraf MN. Preliminary screening of imunocin for immunomodulatory activity. Indian J Pharm Sci. 2000; 62:257.
9. Dahanukar SA, Thatte UM, Pai N, More PB, Karandikar SM. Immunotherapeutic modification byTinospora cordifolia of abdominal sepsis induced by caecal ligation in rats. Indian J Gastroenterol.1988; 7:21–3.
10. Rege NN, Thatte UM, Dahanukar SA. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine, Phytotherapy, Research, 1999; 13:275–91.
11. Thatte UM, Dahanukar SA. Immunotherapeutic modification of experimental infections by Indian medicinal plants. Phytotherapy, Research, 1989; 3:43–9.
12. Thatte UM, Chhabria S, Karandikar SM, Dahanukar SA. Immunotherapeutic modification of E. coli induced abdominal sepsis and mortality in mice by Indian medicinal plants. Indian Drugs.1987; 25:95–7
13. Ranjith MS, Ranjitsingh AJ, Gokul Shankar S, Vijayalaksmi GS, Deepa K, Sidhu HS. Enhanced phagocytosis and antibody production by Tinospora cordifolia: A new dimension in Immunomodulation. Afr J Biotechnol. 2008; 7:81–5)
14,15. Vaidhya Yadavji Trikamji, Siddha Yoga Samgraha- Jwaradhikara 1, 11th edition, Shri Baidhnath Ayurveda Bhavan L., Varanasi; 4.
16. Paget GE, Barnes JM, Evaluation of drug activities and pharmacometrics, Toxicity tests. In: Laurence DR, Bacharach AL, editors. Vol 1, London and N.Y: Academic Press, 1964, 135-66.
17. Puri A, Saxena RP, Saxena KC, Srivastava V, Tandon JS, Immunostimulant activity of Nyctanthes arbortristis L. J Ethenopharmacol 1994;42:31-7
18. Khan T, Tatke P, Gabhe SY, Immunological studies on the aerial roots of the Indian Banyan. Indian J. Pharm Sci 2008; 70:287-91.
19. Raghuramulu N, Nair KM, Kalyanasundaram S. A Manual of laboratory Techniques, Hydrerabad, India: National institute of Nutrition (NIN); 1983; 246-53.
20. Bhattachrya. Manual Pre - conference, Annual conference of Indian Pharmacological society, Workshop on research Methodology in Pharmacology 1993.
21. Bhatt KR, Mehta RK, Srivastava PN, Asimple method to assess anti-inflammatory activity, Ind. J. Physiol Pharmac 1977;21:399.
22. Snedecor GW and Cochran WG, Stastical methods. 6th ed. Ames, lowa: lowa State University Press; 1967:258-96.
23. Thatte, U.M, Rao S G & Dahanukar S A, J. Postgrad. Med., 1994, 40, 202. 24. Chemistry and pharmacology of Ayurvedic medicinal plant, Vd. Mukund sabnis, 2006-341.
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Published
2013-06-30
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Umretia, B., Vaishnav, P., Patgiri, B., Prajapati, P., Shukla, V., & Ravishankar, B. (2013). Immunomodulatory activity of Guduchi Ghana (Aqueous Extract of Tinospora Cordifolia Miers): Immunomodulatory activity of Guduchi Ghana. National Journal of Integrated Research in Medicine, 4(3), 88–94. Retrieved from http://nicpd.ac.in/ojs-/index.php/njirm/article/view/2187
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