Assessment Of Thyroid Function In Euthyroid Obese Medical Students.
Assessment Of Thyroid Function In Euthyroid Obese Medical Students.
Keywords:
Thyroid Stimulating hormone (TSH), free Triidothyronine (fT3), Free thyroxine (fT4), Body Mass Index (BMI)Abstract
Background: It is well known that Thyroid Hormones play a key role in regulating energy
homeostasis. The association between thyroid hormones and energy expenditure is well established. There is
inverse relationship between obesity and energy expenditure. There is a limited data on thyroid function in
euthyroid obese young individuals. Objectives: The present study was designed to evaluate the relationship
between thyroid function and obesity in euthyroid young individuals. Materials & Methods: Obesity was
defined as per Body Mass Index. (BMI)Undergraduate medical students were grouped as normal, overweight
and obese as per their Body Mass Index Thyroid function was assessed by measuring fT3, fT4 and TSH levels by
using automated chemiluminescence immunoassay system. Results: We found that the levels of TSH showed
significant increase in overweight and obese subjects (p< 0.001) however there was no statistical difference in
the levels of fT3and fT4 in overweight and obese students as compared to normal(p> 0.05). Interpretation &
Conclusion: Our results suggest that thyroid function though within the normal range could be one of several
factors acting in concert to determine body weight in a population. Even slightly elevated serum TSH levels are
associated with an increase in BMI.
References
Medicine 21st Ed, McGraw Hill India 2011;
366-367.
2. Overweight and Obesity Fact sheet:
Department of Sustainable Development and
Healthy Environment. September 2011 WHO
Regional office South East Asia.
3. Ganong WF.Ganong’s review of Medical
Physiology 22nded; 2005. Thyroid physiology.
McGraw Hill-Singapore Publications.
4. De Pergola, G., Ciampolillo, A., Paolotti S.,
Trerotoli, P., Giorgino, R. Free
triiodothyronine and thyroid stimulating
hormone are directly associated with waist
circumference, independently of insulin
resistance, metabolic parameters and blood
pressure in overweight and obese women.
Clinical Endocrinology; 2007:67(2) 265-269.
5. Al-Adsani, H., Hoffer, L. J., & Silva, J. E. Resting
energy expenditure is sensitive to small dose
changes in patients on chronic thyroid
hormone replacement. Journal of Clinical
Endocrinology and Metabolism.1997;82
:1118-1125.
6. Bunevicius, A., Peceliuniene, J., Mickuviene,
N., Girdler, S. S., & Bunevicius, R. The
association of thyroid immunity with blood
pressure and body mass index in primary care
patients. Endocrine Research. 2008; 33(3):93-
103.
7. FoxC.S., Michael J. Pencina, Ralph B.
D’Agostino, P Joanne M. Murabito,MD;
Relations of Thyroid Function to Body Weight
Cross-sectional and Longitudinal Observations
in a Community-Based Sample; Arch Intern
Med;Vol 168 (No. 6)Mar 24, 2008: 587-592.
8. Kalmijin S, Mehta KM, Pols HA, Hofman A,
Drexhage HA, Breteler MM. Subclinical
hyperthyroidism and the risk of dementia. The
Rotterdam study.Clin Endocrinol (Oxf) 2000;
53:733 – 737.
9. Centres for Disease Control and
Prevention..Body Mass Index. 2009. Retrieved
from
http://www.cdc.gov/healthyweight/assessing/bmi
10. Knudsen, N., Laurberg, P., Rasmussen, L. B.,
Bulow, I., Perrild, H., Ovesen, L.Jorgensen, T.
Small differences in thyroid function may be
important for body mass index and the
occurrence of obesity in the population.
Journal of Clinical Endocrinology and
Metabolism.2005; 90: 4019-4024.
11. Iacobellis, G., Ribaudo, M. C., Zappaterreno,
A., Iannucci, C. V et al Relationship of thyroid
function with body mass index, leptin, insulin
sensitivity and adiponectin in euthyroid obese
women. Clinical Endocrinology.2005; 62: 487-
491.
12. Sari, R., Balci, M. K., Altunbas, H., &
Karayalcin, U. The effect of body weight and
weight loss on thyroid volume and function in
obese women.Clinical Endocrinology. 2003;
59: 258-262.
13. Knudsen N, Bulow I, Jorgensen T, Laurberg P,
Ovensen L, Perllid H. Comparative study of
thyroid function and types of thyroid
dysfunction in two areas of Denmark with
slightly different iodine status. Eur J
Endocrinol 2000; 143: 485 – 491.
14. Rotondi, M., Leporati, P., La Manna, A., Pirali,
B., Mondello, T., Fonte, R.,Chiovato, L. Raised
serum TSH levels in patients with morbid
obesity: Is it enough todiagnose subclinical
hypothyroidism? European Journal of
Endocrinology, 2009; 160: 403-418.
15. Mehran L, Amouzegar A, Delshad H, Azizi F.
Association between serum tsh concentration
and body mass index in euthyroid subjects:
the role of smoking. Arch Iran Med. 2012;
15(7): 400 – 403.
16. M.H.Eftekhari,H,MozaffariKhosravi,Z.Mazloo
m.Body Mass Index and Thyroid Function in
Adolescent girls. Pakistan Journal of Biological
Sciences.2007;10(6):905-909.
17. Anna Grandone, Nicola Santoro, Filomena
Coppola, Paolo Calabro, Laura Perrone,
Emanuele Miraglia delGiudice. Thyroid
function derangement and childhood obesity:
an Italian experience.BMC Endocrine
Disorders 2010; 10:8.
18. Mebmet B, Fulya A, et al. Obesity is associated
with increased serum TSH level, independent
of thyroid function. SWISS MED WKLY 2007;
13:431- 434.19. Feldt-Rasmussen U. Thyroid and leptin.
Thyroid. 2007; 17: 413 – 419.
20. Manji, N., Boelaert, K., Sheppard, M. C.,
Holder, R. L., Gough, S. C., & Franklyn, J. A.
Lack of association between serum TSH or
free T4 and body mass index in euthyroid
subjects. Clinical Endocrinology. 2006;
64(2):125-128.
21. Shon, H. S., Jung, E. D., Kim, S. H., & Lee, J. H.
Free T4 is negatively correlated with body
mass index in euthyroid women. Korean
Journal of Internal Medicine.2008; 23(2):53-
57.
