Effectiveness Of Interventions Among HIV Reactive Pregnant Women (In Andhra Pradesh)
Interventions Among HIV Reactive Pregnant Women
DOI:
https://doi.org/10.70284/njirm.v4i2.2142Keywords:
Andhra Pradesh, ART, Effectiveness, Nevirapine, PPTCT Program, Retrospective Cohort studyAbstract
Background: Over the years, single dose Nevirapine has been the cornerstone of the PPTCT program in India. However after successful scale up of ART program, initiation of ART for the pregnant was also considered another means of reducing the risk of transmission of HIV. As there were no specific studies to demonstrate the advantages of full-course ART during pregnancy compared to single dose Nevirapine, the current study was undertaken. Objectives: To study the socio-demographic variables, effectiveness of the different interventions and factors affecting the interventions among the PPTCT program beneficiaries.
Materials and Methods: As part of the retrospective cohort study the details of the HIV positive pregnant women registered at four ICTCs of Andhra Pradesh were analyzed in two groups (Nevirapine and ART).
Results: Total 145 pregnant women were studied and among them, 3.4% opted for MTP, 66.2% had live-birth and 60% had normal vaginal delivery. Upon testing for HIV at 18 months, 35% babies were HIV reactive in the Nevirapine group, 17.6% babies were HIV reactive in the ART group. Interpretation & Conclusion: The findings from the present study showed higher protection among babies with mothers on ART before delivery, compared to those with single dose Nevirapine.
References
2. Antiretroviral drugs for treating pregnant women and preventing HIV infection in infants: Towards universal access. Recommendations for a public health approach. World Health Organization. 2006; Page-7.
3. Read J et al. A prospective cohort study of HIV-1-infected pregnant women and their infants in Latin America and the Caribbean: the NICHD International Site Development Initiative Prenatal Study. 12th Conference on Retroviruses and Opportunistic Infections. Boston, MA, USA. 2005 Feb 22-25 (Abstract 790).
4. National AIDS Control Organisation: Department of AIDS Control. Available from:
http://www.nacoonline.org/National_AIDS_Control_Program/Services_for_Prevention/PPTCT/
5. Parameshwari S, Jacob MS, Vijayakumari JJ, Shalini D, Sushi MK, Sivakumar MR. A program on prevention of mother to child transmission of HIV at government hospital, Tiruchengode taluk, Namakkal district. Indian J Community Med 2009; 34:261-3.
6. Mandal S, Bhattacharya RN, Chakraborty M, Pal PP, Roy SG, Mukherjee G. Evaluation of the Prevention of Parent to Child Transmission Program in a Rural Tertiary Care Hospital of West Bengal, India. Indian J Community Med. 2010 Oct-Dec; 35(4): 491–494.
7. Colvin M, Chopra M, Doherty T, Jackson D, Levin J, Willumsen J et al. Operational effectiveness of single-dose Nevirapine in preventing mother-to-child transmission of HIV.
Bulletin of the World Health Organization. 2007 June; 85(6): 466-473.
8. Mother-to-child transmission of HIV infection in the era of highly active antiretroviral therapy. Clinical Infectious Diseases.2005 Feb 1; 40(3):458–465.
9. Dorenbaum A, Cunningham CK, Gelber RD, Culname M, Mofenson L, Britto P et al. Two-dose intrapartum/newborn Nevirapine and standard antiretroviral therapy to reduce prenatal HIV transmission: a randomized trial. Journal of the American Medical Association. 2002; 288(2):189–198.
10. Irene YV, Arun A. Efficacy of Single Dose Nevirapine in Prevention of Mother to Child transmission of HIV-1. J Obstet Gynaecology India (Vol. 60), No. 3: May - June 2010; pg 221-224.
11. Rajesh L, Ramesh K, Hanna LE, Narayanan PR, Swaminathan S. Emergence of drug resistant mutations after single dose nevirapine exposure in HIV-1 infected pregnant women in south India. Indian J Med Res. 2010 November; 132(5): 509-512
