To Investigate the Antioxidant Property of GINGER-JUICE (ZINGIBER OFFICINALE ROSCOE) Using Established Antioxidant Parameters
To Investigate the Antioxidant Property of GINGER-JUICE
DOI:
https://doi.org/10.70284/njirm.v3i2.1989Keywords:
Glutathione peroxidise, Glutathione reductase, Total antioxidant status, ginger-juiceAbstract
Background & objectives: To investigate the Antioxidant property of ginger-juice (G.J) in rat. Methods: Albino rats (n=6-12) were administered G.J at two doses (4ml/rat, p.o) as a chronic treatment over period of 21 days. The liquid portion which was obtained by the course of filtration, looked like yellowish hazy opalescent liquid. ANTIOXIDANT STATUS (FREE RADICALS): Blood samples were used for following antioxidant parameters. 1. Glutathione peroxidise 2. Glutathione reductase 3. Total antioxidant status Results: The chronic administration of G.J (4ml/rat, p.o) over a period of 21 days did not alter any of these parameters except glutathione reductase. Conclusion: G.J rules out the Antioxidants property in form of rise reduced glutathione level was noted
References
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2. Guenther Ernest. “The plant family Zingiberaceae†The essential oils, published by D. Van Nostrand Company Canada. Volume-V 1952; 106-20.
3. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of the erythrocyte glutathione peroxidase. J Leb Clin Med 1967; 70: 158-69.
4. Evans William Charles. Trease and Evans Pharmacognosy, 13th edition. ELBS 1989; 464-468.
5. Kokate C.K, Purohit A.P, Gokhale S.B. Resins and resin combination. Textbook of pharmacology published by Nirali Prakashan Pune. 14th edition 2000; 424-27.
6. Subramaniyam S, Shyama S, Shyamala Devi CS. Oxidant and antioxidant levels in the erythrocytes of breast cancer patients treated with CMF. Med Sci Res 1993; 21:79-80.
7. Miaolin HU, Tappel AI. Glutathione and antioxidant protects against lipid peroxidation and enzyme inactivation lipids 1992; 27:42-5.
8. Cheeseman K H. Slater T F. An introduction to free radical biochemistry. Br Med Bull 1993; 49, 3:481-93.
9. Wegener T, Fintelmann V. Flavonoids and bio-activity, Wein Med Wo chem Schr., 1999; 149:241-7.
10. Ares J J. Outt P E, Gastroprotective agents for the prevention of NSAID-induced gastropathy. Curr Pharm Des 1998; 4: 7-36.
11. Wlexler BC, Greenberg BP. Protective effects of clofibrate on isoproterenol-induced myocardial infarction in arteriosclerotic and non-arteriosclerotic rats. Atherosclerosis 1978; 29:373-375.
12. Kumari Sushma S, Jayadeep A, Suresh Kumar J S, Menon PVG. Effect of carnitine on malondialdehyde, taurine and guanethidine levels in the heart of rats subjected to myocardial stress by isoprotenol. Indian J Exp Biol 1989; 27:134-137.
13. Mistra HP, Fridovich I. The role of superoxide anion in the auto oxidation of epinephrine and a simple assay of superoxide dismutase. J Biol Chem 1972; 247:3170-5.
14. Beutler E. In: Red cell metabolism- A manual of
biochemical methods, 3rd ed., Orlando: Grane and Stratton, 1984.
15. Caliborone AL .In: Handbook of methods for oxygen radical research, Florida: CRC Press, 1985; 283.
16. Barceloux D G. Selenium. Journal of Toxicol Clin Toxicol 1999; 37(2): 145-72.
17. Kenneth H, Falchuk. Disturbances in trace element metabolism. Harrision's Principles of Internal Medicine. 13th Edition 1994; Vol.1, chap.78: 481-483.
18. Halliwell B. How to characterise a biological antioxidant? Free Radic Res Commun 1990; 9,1:1-32.
19. Meister A. Glutathione metabolism and its selective modification. J Biol Chem 1988; 263: 17205-17208.
20. Rathburn WB, Bovis MG. activity of glutathione peroxidase and glutathione reductase in the human lens related to age. Curr Eye Res 1985; 5:381-5.
21. Graw J, Summer KH, Michel C, Boss W. Catalase and Superoxide dismutase activities in lenses of cataractous Nop-mice. Exp Eye Res 1985; 41:577-579.
22. Aeschbach R, Loliger J, Scott B C, Murcia A, Butler J, Halliwell B, Aruoma O I. Antioxidant actions of thymol, carvacrol, 6-gingerol, Zingerone and hydroxytyrosol. Food and Chemical Toxicology 1994; 32, 1: 31-36.
23. Beutler E. GR: Stimulation in normal subjects by riboflavin supplementation Sci 1969; 165:612-615.
24. Acharya C. R. Oxidative stress in aminoglycoside-induced nephrotoxicity. A Dissertation for Degree of M.D. (Pharmacology) submitted to South Gujarat University, Surat 2000; 104-111.
25. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: Biochemical role as a component of glutathione purification and assay .Science 1973; 179:588-90.
26. Nadkarni A K. The Indian Materia Medica with Ayurvedic, Unani and Home remedies. Tatva-vivechaka press Bombay. 1926; 913-919.
27. Caliborone AL .In: Handbook of methods for oxygen radical research, Florida: CRC Press, 1985; 283.
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Published
2012-06-30
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Prasad, D., Vajpeyee, D., & Bhavsar, D. V. (2012). To Investigate the Antioxidant Property of GINGER-JUICE (ZINGIBER OFFICINALE ROSCOE) Using Established Antioxidant Parameters: To Investigate the Antioxidant Property of GINGER-JUICE. National Journal of Integrated Research in Medicine, 3(2), 31–35. https://doi.org/10.70284/njirm.v3i2.1989
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