A Comparative Study of Serum Lipid Profile between Premenopausal And Postmenopausal Women.
Study Of Lipid Profile In Pre And Post Menopausal Women
Keywords:
Serum lipid profile, Premenopausal women, Postmenopausal womenAbstract
Background & objectives: The effect of the hormonal changes associated with menopause on the serum lipid levels may play an important role in most cardiac related disorders associated with menopause. So the present study was undertaken with the following objectives. 1) To study the serum lipid profile in premenopausal and postmenopausal women. 2) To compare the differences of serum lipid profile between premenopausal and postmenopausal women. 3) To study the effect of duration of menopause on serum lipid profile. 4) To correlate the results of present study with that of other studies. Methods: 50 premenopausal and 50 postmenopausal women were recruited for the study. The subjects having risk factors that may affect the lipid profile were excluded. 5 ml of venous blood was collected after overnight fasting of 12 hrs in all the subjects for estimation of serum levels of total cholesterol, HDL, LDL, VLDL and triglycerides. Results: As compared to premenopausal women, mean level of serum total cholesterol and serum LDL were significantly higher in postmenopausal women and level significantly increased with increase in the duration of menopause. While level of serum HDL was significantly lower in postmenopausal women and level significantly decreased with increase in the duration of menopause. There was no statistically significant difference in serum triglycerides and serum VLDL between premenopausal and postmenopausal women up to 10 years duration of menopause. However they increased significantly after > 10 years duration of menopause. Interpretation & conclusion: According to the present study, menopause is associated with altered serum lipid profile and thus an independent risk factor for developing cardiovascular diseases. Therefore it is important to consider each and every postmenopausal woman to undergo screening for abnormal lipid profile. In them, specific health education strategies are needed in an order to prevent the emerging cardiovascular diseases.
References
2. Do K A, A Green, J R Guthrie, E C Dudley, H G Burger and L Dennerstein : Longitudinal study of risk factors for coronary heart disease across the menopausal Transition, American Journal of Epidemiology. 2000 ; 151 : 584-593
3. Berg G, Mesch V, Boero L et al: Lipid and lipoprotein profile in menopausal transition.
Effects of hormones, age and fat distribution. Horm Metab Res. Apr. 2004 ; 36(4) : 215-220
4. J C Igweh, I U Nwagha and J M Okaro: The effects of menopause on the serum lipid profile of normal females of south east Nigeria; Nigerian journal of physiological sciences. 2005 ; 520(1-2) : 48-53
5. Bales A C: In search of lipid balance in older women; new studies raise questions about what works best. Postgrad. Med. 2000 ; 108 (7) : 57-72
6. S A Samaan and M H Crawford: Estrogen and cardiovascular function after menopause, Journal of the American College of Cardiology. 1995 ; 26 : 1403-1416,
7. Stampfer M J and W C Williet: A prospective study of postmenopausal estrogen and coronary heart disease, N.Engl.J.Med. 1999 ; 313 : 1044-1049
8. C A O. Usoro, C C Adikwuru, I N Usoro and A C Nsonwu: Lipid Profile of Postmenopausal Women in Calabar, Nigeria; Pakistan Journal of Nutrition. 2006 ; 5 (1) : 79-82
9. Automated assays for lipid profile http://www.randox.com/brochures/PDF%20Brochure/LT147.pdf.
