Fibroblast Heterogeneity And Its Implications
Fibroblast Heterogeneity And Its Implications
Keywords:
Fibroblast Heterogeneity And Its ImplicationsAbstract
After acute inflammation fibroblasts participate transiently in tissue repair by regulating the structure and function of healthy tissues. They also assume an aberrant stimulatory role during chronic inflammatory states including cancer. Heterogeneity of fibroblast applies to functional and phenotypic properties within or across tissues. Fibroblasts are heterogeneous with respect to functional properties, and that certain subpopulations of these cells may be clonally selected and expanded in diseased tissues. These pleiotropic functions highlight the inherent plasticity of fibroblasts and may provide new pathways to understand and therapeutically intervene in diseases. [Monali S NJIRM 2016; 7(5):92-94]
References
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11. Hassell TM, Stanek EJ 3rd. Evidence that healthy human gingiva contains functionally heterogeneous fibroblast subpopulations. Arch Oral Biol. 1983; 28 (7): 617-25.
12. El Ghalbzouri et al. Fibroblasts facilitate re-epithelialization in wounded human skinequivalents. a journal of technical methods and pathology. 2004; 84:102–112.
13. Bordin S, Costa LG, Tan X. Fibroblast heterogeneity of signal transduction mechanisms to complement-C1q. Analyses of calcium mobilization, inositol phosphate accumulation, and protein kinases-C redistribution. J Periodontol. 1998; 69 (6): 642-9.
2. Archana1, Srikanth V,Sasireka, Kurien B, Ebenezer. Fibroblast Heterogeneity in Periodontium – a Review. International Journal of Dental Sciences and Research 2014; 2(3): 50-54.
3. Lekic PC, Pender N, McCulloch CA. Is fibroblast heterogeneity relevant to the health, diseases and treatments of periodontal tissues? Crit Rev Oral Biol Med.1997; 8: 253-68.
4. Irwin CR, Picardo M, Ellis I, Sloan P, Grey A, McGurk M, Schor SL. Inter- and intra-site heterogeneity in the expression of fetal-like phenotypic characteristics by gingival fibroblasts: potential significance for wound healing. J Cell Sci.1994; 107 (5):1333-46.
5. McCulloch CA, Bordin S. Role of fibroblast subpopulations in periodontal physiology and pathology. J Periodontal Res. 1991;26 (3):144-54.
6. McCulloch CA, Knowles G. Discrimination of two fibroblast progenitor populations in early explant cultures of hamster gingiva. Cell Tissue Res.1991;264 (1): 87-94.
7. Ko SD, Page RC, Narayanan AS. Fibroblast heterogeneity and prostaglandin regulation of subpopulations. Proc Natl Acad Sci U S A. 1977; 74 (8): 3429-32.
8. Hakkinen L, Larjava H. Characterization of fibroblast clones from periodontal granulation tissue in vitro. J Dent Res. 1992; 71 (12): 1901-7.
9. Barcellos-Hoff, M.H., and S.A. Ravani.. Irradiated mammary gland stroma promotes the expression of tumorigenic potential by un irradiated epithelial cells. Cancer Res. 60:1254–1260.
10. Gopu Srirama,1, Paul Lorenz Bigliardi a,b,c, Mei Bigliardi-Qi a, Fibroblast heterogeneity and its implications for engineering organotypic skin models in vitro. European Journal of Cell Biology.2015; 94: 483–512.
11. Hassell TM, Stanek EJ 3rd. Evidence that healthy human gingiva contains functionally heterogeneous fibroblast subpopulations. Arch Oral Biol. 1983; 28 (7): 617-25.
12. El Ghalbzouri et al. Fibroblasts facilitate re-epithelialization in wounded human skinequivalents. a journal of technical methods and pathology. 2004; 84:102–112.
13. Bordin S, Costa LG, Tan X. Fibroblast heterogeneity of signal transduction mechanisms to complement-C1q. Analyses of calcium mobilization, inositol phosphate accumulation, and protein kinases-C redistribution. J Periodontol. 1998; 69 (6): 642-9.
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Published
2018-01-24
How to Cite
Shah, M., Patel, A., Patel, S., & Surani, J. (2018). Fibroblast Heterogeneity And Its Implications: Fibroblast Heterogeneity And Its Implications. National Journal of Integrated Research in Medicine, 7(5), 92–94. Retrieved from http://nicpd.ac.in/ojs-/index.php/njirm/article/view/1150
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Review Article
