Effect Of Sex Hormonal Changes On Serum Lipid Profile In Diabetic And Non-Diabetic Indian Females
Effect Of Sex Hormonal Changes On Serum Lipid Profile In Diabetic
DOI:
https://doi.org/10.70284/njirm.v6i6.1013Keywords:
Sex hormones, lipid profile, diabetic females, menopauseAbstract
important determinants in the development of coronary heart disease (CHD) in females. The present work was envisaged to study the effect of sex hormonal changes on serum lipids in females of different age groups and physiological status i.e. menstruation and menopause. Methodology: The comparisons were made between diabetic females of both the phases (menstruation and menopause) and age matched non-diabetic females. Further comparisons were made between diabetic females of menopause phase and diabetic females of menstruation phase. Results: In the study when comparisons were made between menstruating diabetics and menstruating non-diabetics, the former group showed significant increase in plasma glucose, serum total cholesterol (TC), Triglyceride (TG), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels. Similarly comparisons were made between menopausal diabetics and menopausal non-diabetics, the former group showed significantly higher levels of plasma glucose, serum TC, TG, LDL and VLDL. However it is noticed that HDL levels did not very significantly in both the comparisons. Also in diabetic menopausal females there is a significant increase in serum TG levels as compared to diabetic menstruating females. Conclusions: In present study, in non-diabetic menopausal females there is a significant increase in plasma glucose, serum TC, TG, LDL and VLDL concentration levels as compared to non-diabetic menstruating females. Also in diabetic menstruating and menopausal females, there is a significant increase in plasma glucose, TC, TG and VLDL levels as compared to non-diabetic menstruating and menopausal females. [Patel H NJIRM 2015; 6(6):35-38]
References
2. Thom T.J. Cardiovascular disease mortality in U.S. Women. In: Coronary heart disease in women. Eds, Eaker E, Packard B, Wenger N, Clarkson T, Tyroler H A, Haymarket B Doyma, New York, 1987; edition: 33 -41.
3. Brown B.G, Zhao X.Q, Sacco D.E, Albers J.J. Atherosclerosis regression, plague disruption and cardiovascular events: a rational for lipid lowering in coronary artery disease. Ann. Rev. of Med. 1993; 44: 365 –376.
4. Abbott W, Lillioja S. and Yong A. Relationships between plasma lipoprotein concentrations and insulin action in an obese, hyperinsulinaemic population. Diabetes.1987; 36: 897 - 904.
5. Trinder P. Determination of Glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann. Cinin. Biochem.1969; 6: 24-27.
6. Allain C.C, Poon L.S, Chan C.S.G, Richmond W and Fu P.C. Enzymatic determination of total cholesterol. Clin. Chem. 1974; 2O: 470-475.
7. McGowan M.W, Arties J.D, Strandbergh D.R. et al. A peroxidase coupled method for colorimetric determination of serum triglycerides. Clin.Chem.1983; 29: 538-542.
8. Lopes–Virella M.F, Stone P, Ellis S. et al. Cholesterol determination in high density lipoproteins separated by three different methods. Clin. Chem. 1977; 23:882.
9. Ratcliffe W. A. et al. Estradiol assay: applications and guidelines for the provision of a clinical biochemistry service. Ann. Clin. Biochem.1983; 25: 466-483.
10. Wood P. Groom G, Moore A, Ratcliffe W and Selby C. Progesterone assay: guidelines for the provision of clinical biochemistry service. Ann. Clin. Biochem.1985; 22 (Part-1):1-24.
11. Friedwald W. T, Levy R. I. and Fredrickson D.S. Estimation of the concentration of LDL cholesterol without the use of preparative ultracentrifuge. Clin. Chem.1972; 18: 499-502.
12. Some M.R, Osnago - Gadda I, Paoletti R, Fumagalli R, Morrisett J. D. et al. The lowering of lipoprotein (a) induced by estrogen plus progesteronereplacement therapy in post-menopausal women. Arch. of Inte. Medicine. 1993; 153: 1462-1468.
13. Bush T, Cowan L, Heiss G, Chambliss L. and Wallace R. Ovarian function and lipid/lipoprotein levels. Results from the Lipid Research Clinics (LRC) programme (abstract) Am. J. Epidemiol.1984; 120:489.
14. Bengtsson C, Lapidus L. and Lindquist O. Association between menopause and risk factors for ischaemic heart disease. Op. Cit. 1986; 93-102.
15. Fernando Lizcano and Guillermo Guzmán. Estrogen Deficiency and the Origin of Obesity during Menopause. Bio Med Research International. 2014; Volume 2014, Article ID 757461, 11 pages
